Specific radioimmunoassay of amitriptyline and nortriptyline.
نویسندگان
چکیده
منابع مشابه
Quantitative homogeneous enzyme immunoassays for amitriptyline, nortriptyline, imipramine, and desipramine.
We describe specific EMIT homogeneous enzyme immunoassays for amitriptyline, nortriptyline, imipramine, and desipramine in patients' serum samples. Before analysis, an easily performed extraction step involving the use of 500 microL of sample and a 1-mL disposable column eliminates cross-reacting polar metabolites. The range of the standard curve for the first three drugs is 25 to 250 microgram...
متن کاملMeasurement of plasma nortriptyline concentrations: radioimmunoassay and gas-chromatography compared.
We compared measurement of plasma nortriptyline by a recently developed radioimmunoassay technique with values obtained by traditional gas chromatography. The coefficient of correlation (r) was 0.98 for 84 samples from 21 controlled patients; for a separate series of 45 samples from 34 patients who were receiving in addition other medication, r was 0.96. Use of radioimmunoassay in the routine d...
متن کاملA radioimmunoassay for nortriptyline (and other tricyclic antidepressants) in plasma.
The radioimmunoassay for nortriptyline described here can detect as little 1 microgram/liter of plasma. Within-day precision and day-to-day precision (CV) were +/- 6 and +/- 11%, respectively, over the concentration range 100-200 microgram/liter. The major metabolite hydroxy-nortriptyline, does not cross react with the antiserum. Results so obtained correlate closely with results by a double-is...
متن کاملElectrochemical Study of Some Charge-Transfer Complexes Involving Amitriptyline and Nortriptyline and Determination of Drugs
Spectrophotometric and electrochemical studies were successfully used in quantitative analysis of Amitriptyline Hydrochloride (ATH) and Nortriptyline Hydrochloride (NTH). Conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. Two new methods using spectrophotometry are dascribed for the determination of (ATH) and (NTH) with potassium b...
متن کاملPhotosensitized Degradation of Amitriptyline and Its Active Metabolite Nortriptyline in Aqueous Fulvic Acid Solution.
Amitriptyline is a frequently prescribed tricyclic antidepressant. Although amitriptyline and its active metabolite, nortriptyline, have been widely detected in natural waters, their environmental fate due to photodegradation is poorly understood. Here we describe a study conducted to investigate the photodegradation of amitriptyline and its active metabolite under simulated sunlight. Neither a...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1979
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1979.tb00943.x